Fenbendazole (FZ), a broad-spectrum anti-parasitic drug that is used in veterinary medicine, has now been found to have a promising potential for cancer treatment. Researchers at the National Centre for Human Genome Studies and Research (NCHGSR), Panjab University, have shown that it kills cancer cells by causing cell death and activating p53.
How Does Fenben Work?
A recent Facebook post boasted a fenben miracle cure, claiming that the dog wormer ingredient, spelt fenben, was an effective cancer cure. Despite the claims, there is no evidence to back it up. Nevertheless, one Oklahoma businessman was treated with the drug and is now cancer free.
As an anthelmintic, spelt fenben has been around for decades and is used in the fight against parasitic infestations in dogs. There is a modest amount of evidence to support the claim that the fenben is an effective and safe treatment for human cancer, but no studies have been conducted to verify this. The pill’s most impressive function is to inhibit the growth of tumors, and the best results were achieved with a single dose. Moreover, it has been shown to be particularly effective at targeting the most cancerous cells, especially in the brain and lungs. This is an exciting and promising new direction for the pharma industry.
Fenben Kills Cancer Cells
The fenben pill kills cancer cells in two ways. One is by shutting down a cancer cell’s ability to grow and spread. The other is by killing the cancer cells themselves.
In one study, fenbendazole caused apoptosis in SNU-C5 and SNU-C5/5-FUR colorectal cancer cells. Apoptosis was triggered via reduced autophagy and increased ferroptosis. Apoptosis was also triggered by decreased GPX4 expression and p53 activation.
Researchers also found that fenbendazole induced cell cycle arrest in SNU-C5 and SNU-C5/5-FUR cells. This was accompanied by an increase in p21 expression.
These findings suggest that fenbendazole kills cancer cells without affecting normal cells. As a result, it is potentially a promising treatment for some types of cancer.
Fenben Causes Cancer Cell Death
fenben for cancer cell death by inhibiting a number of well-studied mechanisms that control how cells die. Two of these are apoptosis and autophagy.
Apoptosis occurs when a cell can no longer function normally and starts to break down, digest, and eventually die. This can happen for a number of reasons, such as when a tumor has mutations that allow it to grow out of control.
These tumors can also have other mutations that cause them to divide and form new tumors. That’s why researchers want to know more about what causes this process.
Fortunately, there are many different types of cell death, all with their own unique characteristics and processes. For instance, some of these processes are triggered when a cell is sick or stressed.
For example, a cancer cell will often increase its energy needs by taking in more glucose than normal cells. Fenben blocks glucose uptake by preventing cancer cells from taking in the energy they need, which helps to kill the cancer cells.
Fenben is Safe
Fenben is a drug that’s typically used in veterinary medicine to treat parasites and worms (roundworms, hookworms, whipworms, etc.) but now it’s also being used by people in a cancer treatment method known as the Joe Tippens Protocol.
Researchers at the National Centre for Human Genome Studies and Research in Panjab University, India, have found that fenbendazole can prevent tumor engraftment. The study published in Scientific Reports indicates that fenbendazole can kill cancer cells through a combination of moderate microtubule disruption, p53 stabilization and interference with glucose metabolism.
The anti-cancer effects of fenbendazole were further tested on EMT6 cells in vitro, using a rigorous colony formation assay. The researchers saw that fenbendazole reduced the clonogenicity of EMT6 cells in culture, as well as reducing the number of EMT6 cells.